Association between imaging response and survival following neoadjuvant chemotherapy in patients with resectable colorectal liver metastases: A cohort study

Background The association between the imaging response (structural or metabolic) to neoadjuvant chemotherapy (neoCT) before colorectal liver metastasis (CRLM) and survival is unclear. Method A total of 201 patients underwent their first CRLM resection. 94 (47%) were treated with neoCT. multivariable, Cox proportional hazard regression analysis was performed compare overall (OS) progression-free (PFS) groups. Results Multivariable CT/MRI (n = 94) group showed no difference in (OS PFS) who had stable disease/partial (SD/PR) complete (CR) versus progressive disease (PD) (OS: HR, 0.36 (95% CI: 0.11–1.19) p .094, 0.78 0.13–4.50) .780, respectively), (PFS: 0.70 0.36–1.35) .284, 0.51 (0.18–1.45) .203, respectively). In FDG-PET 60) there death for SD/PR CR PD OS PFS except small subgroup 0.75 0.11–4.88) .759, 1.21 0.15–9.43) .857), 0.34% 0.09–1.22), .097, 0.17 0.04–0.62) .008, Conclusion There convincing evidence neoCT following